Meet Bentley! Would you believe this pup has ALSO taken a peptide? This guy is on BPC 157 to help him with GI issues and joint problems. , This week on the pod is all about peptides. Are they safe? Internet famous peptides like BPC 157 and TB 500 might be the future, but right now they're a shot in the dark. Peptides are often well tolerated, but they can still cause temporary reactions while the body adapts. Some commonly reported effects include: BPC 157 headaches, nausea, increased appetite TB 500 Peptide side effects no one talks about BPC 157 headaches. TB 500 fatigue. CJC Ipamorelin water retention. Most people quit. But 90% of the time it's the protocol, not the peptide.