File:Glutathion metabolism DE state in G6PD deficiency.png Wikimedia Commons Pharmacological targeting of glucose 6 phosphate dehydrogenase in human erythrocytes by Bay 117082, parthenolide and dimethyl fumarate Scientific Reports A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway Nature Chemical Biology G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No
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glutathione g6pd Glucose-6-Phosphate Dehydrogenase Deficiency Activates Endothelial Cell and Leukocyte Adhesion Mediated via the TGFβ/NADPH Oxidases/ROS Signaling Pathway