Ferroptosis contributes to ethanol induced hepatic cell death via labile iron accumulation and GPx4 inactivation Cell Death Discovery Manage Acetaldehyde Hangover: Strategies for Effective Recovery SURVIVOR Combination of Cysteine and Glutathione Prevents Ethanol Induced Hangover and Liver Damage by Modulation of Nrf2 Signaling in HepG2 Cells and Mice Your liver needs time to turn ethanol into acetate. If you drink too fast, that "hangover chemical" (acetaldehyde) piles up and ruins the fun. Drink slow and give your enzymes a break.