Regulation of Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance ScienceDirect Tolerance and Desensitization Springer Nature Link Your dopamine system is broken. And it's not your fault. Every app on your phone is engineered to exploit your brain's reward circuitry. Here's the problem: Dopamine doesn't create pleasure. It Schematic representation of receptor desensitization and sequestration Download Scientific Diagram