L glutamine for sickle cell disease: more than reducing redox Annals of Hematology Springer Nature Link In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Glutathione, Erythrocytes Doctor's Data Kit Brighter Life Labs Response of Human Red Blood Cells to Acute and Chronic Oxidant Challenge as Observed Through the Glutathione and Glutathionyl Hemoglobin Redox Pairs In Vitro and In Vivo